863588-32-3
863588-32-3
Chemical Structure
ML-180
Synonym(s): SR1848
- CAS No.: 863588-32-3
- Formula:C20H25ClN4O2
- Molecular Weight:388.89
IUPAC Name: 6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione
InChIKey: CHMQQIFPOIZPIJ-UHFFFAOYSA-N
SMILES: O=C1N(C2CCCCC2)C(C=C(N3CCN(C4=CC=CC(Cl)=C4)CC3)N1)=O
Biological Activity: ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML-180 | 99.96% | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-110329ML179 -
Similarity Score 0.53
HY-164031Cloperidone -
Similarity Score 0.52
HY-164031ACloperidone hydrochloride -
Similarity Score 0.51
HY-Z8656Trazodone impurity 14 -
Similarity Score 0.51
HY-W587508Trazodone impurity 7 -
Similarity Score 0.51
HY-157392hMAO-A-IN-1 -
Similarity Score 0.51
HY-W725833Trazodone impurity 7 dihydrochloride -
Similarity Score 0.49
HY-147398Dopamine D4 receptor antagonist-1 -
Similarity Score 0.48
HY-182974DCAF1 binder 3 -
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