Cloperidone hydrochloride
Cloperidone hydrochloride acts as an inhibitor and substrate of CYP2C9, with an IC50 of 17.7 μM. Cloperidone hydrochloride exhibits enhanced cytotoxicity in cells expressing CYP2C9. It can be used in the research of sedative/hypnotic-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 525-26-8
- Formula: C21H24Cl2N4O2
- Molecular Weight:435.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP2C9 17.7 μM (IC50) |
Cloperidone (0.3-100 μM; 6 min preincubation, 15 min incubation with substrate) hydrochloride potently inhibits recombinant CYP2C9 microsomes, with an IC50 of 17.7 μM[1].
Cloperidone (0-60 min) hydrochloride can be metabolized by recombinant CYP2C9 supersomes to produce a variety of distinct oxidative metabolites[1].
Cloperidone (100 μM) hydrochloride exhibits enhanced cytotoxicity in HepG2 cells expressing CYP2C9, reducing cell viability to 40% of the baseline level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 525-26-8
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Molecular Weight 435.35
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Formula C21H24Cl2N4O2
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SMILES
O=C1NC2=C(C(N1CCCN3CCN(CC3)C4=CC(Cl)=CC=C4)=O)C=CC=C2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Goldwaser E, et al. Machine learning-driven identification of drugs inhibiting cytochrome P450 2C9. PLoS Comput Biol. 2022 Jan 26;18(1):e1009820. [Content Brief]
[2]. Estrada E, et al. Designing sedative/hypnotic compounds from a novel substructural graph-theoretical approach. Journal of computer-aided molecular design. 1998 Nov;12(6):583-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cloperidone hydrochloride Related Classifications
HY-164031A Related Classifications
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