1 Result for "

NU8165

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "NU8165" in MCE Product Catalog:

Cat. No.: HY-122038
CAS No.: 849723-20-2
Target:  

MDM-2/p53

Research Areas:  

Cancer

NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines .
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