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Results for "

PFK-1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123981
    5MPN
    3 Publications Verification

    		 Phosphatase Cancer
    5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines [1].
    5MPN
  • HY-170404
    KF-52

    		Phosphatase Metabolic Disease
    KF-52 is a phosphofructokinase-1 (PFK1) inhibitor with an IC50 value of 2.1 μM. KF-52 significantly increases the ratio of oxygen consumption rate (OCR) to extracellular acidification rate (ECAR). KF-52 is applicable to research related to mitochondrial dysfunction [1].
    KF-52
  • HY-P2819
    Phosphofructokinase 1

    PFK1

    		 Phosphatase Metabolic Disease
    Phosphofructokinase 1 (PFK1) is a major regulatory enzyme targeting glycolytic pathway. Phosphofructokinase 1 catalyzes the phosphorylation of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP) to regulate glycolytic flux. Phosphofructokinase 1 is promising for research of cancer metabolic reprogramming (e.g., hypoxia adaptation, oxidative stress resistance) and metabolic syndromes [1].
    Phosphofructokinase 1
  • HY-149960
    Antiparasitic agent-17

    		Parasite Infection
    Antiparasitic agent-17 (compound 5u) is an orally active antiparasitic agent. Antiparasitic agent-17 inhibits Chloroquine sensitive (Pf3D7) and Chloroquine resistant (PfK1) strain with IC50s of 0.96 μM and 1.67 μM, respectively [1].
    Antiparasitic agent-17
  • HY-149919
    Antimalarial agent 23

    		Parasite Infection
    Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin [1].
    Antimalarial agent 23
  • HY-173312
    Antimalarial agent 49

    		Parasite Infection
    Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection [1].
    Antimalarial agent 49
  • HY-RS10366
    PFKM Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PFKM Human Pre-designed siRNA Set A contains three designed siRNAs for PFKM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PFKM Human Pre-designed siRNA Set A
    PFKM Human Pre-designed siRNA Set A
  • HY-170404A
    KF-52 enantiomer

    		Phosphatase Metabolic Disease
    KF-52 enantiomer is an enantiomer of KF-52 (HY-170404). KF-52 is a phosphofructokinase-1 (PFK1) inhibitor [1].
    KF-52 enantiomer

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