1 Result for "

PPACK TFA

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "PPACK TFA" in MCE Product Catalog:

2
PPACK TFA
PPACK TFA
0 Images
2 Cited Publications
Cat. No.: HY-122542B
CAS No.: 157379-44-7
Purity:  99.28%
Target:  

Protease Activated Receptor (PAR) Thrombin NF-κB

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

PPACK TFA is a potent, peptidic inhibitor targeting thrombin and granzyme GZMK. PPACK TFA specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1 cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, PPACK TFA exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. PPACK TFA binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. PPACK TFA is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases .
loading...
    loading...
View All Sizes
Assay Types