1 Result for "

Pegsebrenatide

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Pegsebrenatide" in MCE Product Catalog:

Pegsebrenatide
Pegsebrenatide
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Cat. No.: HY-P10019
CAS No.: 2243292-26-2
Synonyms: NLY01
Target:  

GCGR

Research Areas:  

Neurological Disease Inflammation/Immunology

Pegsebrenatide (NLY01) is a blood-brain barrier-penetrant GLP-1R agonist. Pegsebrenatide alleviates retinal inflammation and neuronal death secondary to ocular hypertension . Pegsebrenatide significantly delays onset and reduces disease severity in experimental autoimmune encephalomyelitis . Pegsebrenatide inhibits the formation of A1 reactive astrocytes in nerve cells and reduces the loss of retinal ganglion cells and dopaminergic neurons. Pegsebrenatide exerts neuroprotective effects in a mouse model of Parkinson's disease by directly preventing microglia-mediated conversion of astrocytes to the A1 neurotoxic phenotype. Pegsebrenatide can be used for research on glaucoma, Parkinson's disease, and multiple sclerosis .
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