1 Result for "

Pestanoid A

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Pestanoid A" in MCE Product Catalog:

Pestanoid A
Pestanoid A
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Cat. No.: HY-N12561
Category:  

Microorganisms Terpenoids Diterpenoids

Target:  

ERK p38 MAPK JNK

Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC50 of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .
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