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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Phosphofructokinase1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Phosphofructokinase1" in MCE Product Catalog:
Target:
Research Areas:
Phosphofructokinase 1 (PFK1) is a glycolytic enzyme and also an allosteric activation target of fructose-2,6-bisphosphate. PFK1 supports cardiac glycolysis to maintain normal cardiac function and mediates adaptive responses to pressure overload. Upregulated expression and activity of PFK1 are associated with the alleviation of pathological changes induced by pressure overload, including diastolic dysfunction, interstitial fibrosis and myocardial hypertrophy. Inhibition of PFK1 redirects glucose carbon flux to the pentose phosphate pathway. PFK1 promotes proliferation, migration and glycolysis of colorectal cancer cells, reduces apoptosis and decreases their radiosensitivity, and shows higher expression levels in radioresistant tumors. PFK1 can be used in research related to diastolic dysfunction heart failure and colorectal cancer [1] .
Cat. No.: HY-170404
CAS No.: 3104612-74-7
Target:
Research Areas:
KF-52 is a phosphofructokinase-1 (PFK1) inhibitor with an IC50 value of 2.1 μM. KF-52 significantly increases the ratio of oxygen consumption rate (OCR) to extracellular acidification rate (ECAR). KF-52 is applicable to research related to mitochondrial dysfunction [1].
Cat. No.: HY-170404A
CAS No.: 3104612-73-6
Target:
Research Areas:
KF-52 enantiomer is an enantiomer of KF-52 (HY-170404). KF-52 is a phosphofructokinase-1 (PFK1) inhibitor [1].
Cat. No.: HY-P71090
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PFKM; Phosphofructokinase Muscle Isoform 4; Prev. PFKX; 6-Phosphofructokinase, Muscle Type; Phosphofructo-1-Kinase Isozyme A; 6-Phosphofructo-1-Kinase; 6-Phosphofructokinase Type A; Phosphofructokinase 1; Phosphohexokinase; Phosphofructokinase-M; PPP1R122
Cat. No.: HY-P74635
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PFKM; Phosphofructokinase Muscle Isoform 4; Prev. PFKX; 6-Phosphofructokinase, Muscle Type; Phosphofructo-1-Kinase Isozyme A; 6-Phosphofructo-1-Kinase; 6-Phosphofructokinase Type A; Phosphofructokinase 1; Phosphohexokinase; Phosphofructokinase-M; PPP1R122
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
