1 Result for "

Polyphyllin D

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Polyphyllin D" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N2382
CAS No.: 81917-50-2
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 μM, competitive), CYP2D6 (IC50 = 13.88 μM, competitive) and CYP3A4 (IC50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .
loading...
    loading...