3 Results for "

Pomalidomide-C2-NH2

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Pomalidomide-C2-NH2" in MCE Product Catalog:

Cat. No.: HY-128846A
CAS No.: 2305369-00-8
Purity:  99.32%
Synonyms: Cereblon Ligand-Linker Conjugates 15 hydrochloride
Research Areas:  

Cancer

Pomalidomide-C2-NH2 (Cereblon Ligand-Linker Conjugate 15) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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Cat. No.: HY-128846
CAS No.: 1957235-66-3
Synonyms: Cereblon Ligand-Linker Conjugates 15
Research Areas:  

Cancer

Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.
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Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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