2 Results for "

RG7450

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "RG7450" in MCE Product Catalog:

Cat. No.: HY-P990673
Synonyms: DSTP-3086S Antibody; RG-7450 Antibody

Research Areas:  

Cancer

Vandortuzumab (DSTP-3086S Antibody; RG-7450 Antibody) is a humanized anti-STEAP1 IgG1 antibody and antimitotic agent that can be conjugated with MMAE (HY-15162) to form the antibody-drug conjugate (ADC) Vandortuzumab vedotin. Vandortuzumab vedotin specifically binds to STEAP1 and drives internalization of the complex, releasing the MMAE (HY-15162) payload intracellularly. After binding to tubulin, MMAE inhibits cell division and induces cell death. Vandortuzumab exhibits antitumor activity in preclinical xenograft models of prostate cancer and can be used for research related to metastatic castration-resistant prostate cancer (mCRPC) .
loading...
    loading...
Cat. No.: HY-P99528
CAS No.: 1471985-92-8
Synonyms: DSTP 3086S; RG 7450; MSTP2109A

Research Areas:  

Cancer

Vandortuzumab vedotin (DSTP 3086S; RG 7450) is a STEAP1-targeted antibody-drug conjugate (ADC). Vandortuzumab vedotin binds specifically to STEAP1, triggers internalization of the conjugate complex, mediates intracellular release of monomethyl auristatin E, inhibits cell division, and induces cell death. Vandortuzumab vedotin exhibits antitumor activity in preclinical prostate cancer xenografts. Vandortuzumab vedotin can be used for the research of metastatic castration-resistant prostate cancer .
loading...
    loading...