2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Vandortuzumab vedotin

Vandortuzumab vedotin  (Synonyms: DSTP 3086S; RG 7450; MSTP2109A)

Cat. No.: HY-P99528 Purity: 99.52%
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Vandortuzumab vedotin (DSTP 3086S; RG 7450) is a STEAP1-targeted antibody-drug conjugate (ADC). Vandortuzumab vedotin binds specifically to STEAP1, triggers internalization of the conjugate complex, mediates intracellular release of monomethyl auristatin E, inhibits cell division, and induces cell death. Vandortuzumab vedotin exhibits antitumor activity in preclinical prostate cancer xenografts. Vandortuzumab vedotin can be used for the research of metastatic castration-resistant prostate cancer.

For research use only. We do not sell to patients.

CAS No. : 1471985-92-8

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Vandortuzumab vedotin Related Antibodies

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Description

Vandortuzumab vedotin (DSTP 3086S; RG 7450) is a STEAP1-targeted antibody-drug conjugate (ADC). Vandortuzumab vedotin binds specifically to STEAP1, triggers internalization of the conjugate complex, mediates intracellular release of monomethyl auristatin E, inhibits cell division, and induces cell death. Vandortuzumab vedotin exhibits antitumor activity in preclinical prostate cancer xenografts. Vandortuzumab vedotin can be used for the research of metastatic castration-resistant prostate cancer[1].

Species Reactivity

Human
IC50 & Target

STEAP1
Gene ID

26872  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Vandortuzumab vedotin]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Vandortuzumab vedotin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vandortuzumab vedotin1471985-92-8DSTP 3086S RG 7450 MSTP2109ARG7450RG 7450RG-7450Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesprostate cancer xenograftsmonomethyl auristatin Emetastatic castration-resistant prostate cancerantibody-drug conjugatecell divisionSTEAP1cell deathInhibitorinhibitorinhibit

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