STEAP1 - STEAP family member 1 Gene

Also Known as STEAP; PRSS24

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26872

About STEAP1

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,154,469-90,164,827 (from NCBI)

This gene has 3 transcripts (splice variants), 143 orthologues and 4 paralogues. Biased expression in prostate (RPKM 54.6), appendix (RPKM 20.3) and 9 other tissues.

Summary

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple Cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

STEAP1 Products (1)

mRNA Protein Name
NM_012449.3 NP_036581.1 metalloreductase STEAP1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables ferric-chelate reductase (NADPH) activity IDA
IDA: Inferred from direct assay
32409586 GOA
enables heme binding IDA
IDA: Inferred from direct assay
32409586 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
32409586 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STEAP1 Protein Structure

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (119 - 263)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

metalloreductase STEAP1

  • STEAP1 metalloreductase

Related Diseases

Diseases Alias
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Aceruloplasminemia

  • Cerebellar Ataxia

  • Hypoceruloplasminemia

  • Hemosiderosis, Systemic, Due To Aceruloplasminemia

  • Familial Apoceruloplasmin Deficiency

  • Hereditary Ceruloplasmin Deficiency

  • Deficiency Of Ferroxidase

  • Hypoceruloplasminemia, Hereditary

  • Ceruloplasmin Deficiency

  • Systemic Hemosiderosis Due To Aceruloplasminemia

  • ACERULOP
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990688 Xaluritamig Inhibitor ≥99% Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138635 PROTAC BRD4 Degrader linker conjugate-3 Inhibitor 98.54% Unkown
HY-138632 PROTAC BRD4 Degrader linker conjugate-1 Degrader 98.98% Unkown
HY-138633 PROTAC BRD4 Degrader linker conjugate-2 Inhibitor 99.75% Unkown
HY-RS13905 STEAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13906 STEAP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16998 Steap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23441 Steap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990673 Vandortuzumab Inhibitor 99.00% Unkown
HY-P99528 Vandortuzumab vedotin 99.52% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STEAP1 MGD MGI:1917608
Rattus norvegicus STEAP1 RGD RGD:1311543
Others STEAP1 NCBI