6 Results for "

RMI1

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "RMI1" in MCE Product Catalog:

Cat. No.: HY-RS12014
Research Areas:  

Others

RMI1 Human Pre-designed siRNA Set A contains three designed siRNAs for RMI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS20335
Research Areas:  

Others

Rmi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rmi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS26843
Research Areas:  

Others

Rmi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rmi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P11224
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

RMI-L4 is an efficient cyclic peptide inhibitor that can specifically disrupt the interaction between FANCM and RMI proteins with an IC50 of 54 nM. RMI-L4 engages the FANCM-binding pocket of RMI1/2 with nanomolar affinity (KD = 2.5 nM). RMI-L4 cannot penetrate the cell membrane and can be used to study the FANCM-RMI pathway targeting cancer with alternate lengthening of telomeres (ALT) [1].
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Cat. No.: HY-P11841
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma [1].
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Cat. No.: HY-P11842
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

Ac-HFKLYWPPFLGS-NH2 is a RMI1/2 heterodimer inhibitor with an IC50 of 99 nM and antiproliferative activity. Ac-HFKLYWPPFLGS-NH2 binds competitively at the FANCM-RMI interaction interface, mimics native FANCM MM2 domain hydrophobic interactions, and adopts a unique binding pose with additional protein interactions. Ac-HFKLYWPPFLGS-NH2 induces antiproliferative effects in ALT-positive osteosarcoma cells. Ac-HFKLYWPPFLGS-NH2 shows limited stability toward α-chymotrypsin-mediated enzymatic degradation in vitro. Ac-HFKLYWPPFLGS-NH2 lacks inherent cell permeability, requiring conjugation to a cell-penetrating peptide for intracellular delivery. Ac-HFKLYWPPFLGS-NH2 can be used for the research of ALT-positive osteosarcoma [1].
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