RMI-L4
RMI-L4 is an efficient cyclic peptide inhibitor that can specifically disrupt the interaction between FANCM and RMI proteins with an IC50 of 54 nM. RMI-L4 engages the FANCM-binding pocket of RMI1/2 with nanomolar affinity (KD = 2.5 nM). RMI-L4 cannot penetrate the cell membrane and can be used to study the FANCM-RMI pathway targeting cancer with alternate lengthening of telomeres (ALT).
For research use only. We do not sell to patients.
- Formula: C80H111N15O21S
- Molecular Weight:1650.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Chemical Information
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Molecular Weight 1650.89
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Formula C80H111N15O21S
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Sequence
cyclo(Ac-Tyr-Ser-Ile-Leu-Phe-Asp-Lys-Tyr-Tyr-Ser-Ile-Pro-Cys-NH2)
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Sequence Shortening
cyclo(Ac-YSILFDKYYSIPC-NH2)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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