2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. tP4-CPP12

tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma.

For research use only. We do not sell to patients.

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tP4-CPP12

tP4-CPP12 Chemical Structure

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tP4-CPP12 Related Antibodies

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Description

tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma[1].

In Vitro

tP4-CPP12 (6.75-12.5 µM, serial dilutions; 72 h) selectively induces antiproliferative effects in ALT-positive U-2 OS osteosarcoma cells with an IC50 of 8.8 µM, with a more pronounced effect than on telomerase-positive SJSA-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

tP4-CPP12 Related Antibodies

Cell Viability Assay[1]

Cell Line: ALT-positive osteosarcoma U-2 OS cells, telomerase-positive osteosarcoma SJSA-1 cells
Concentration: 6.75 and 12.5 µM
Incubation Time: 72 h
Result: Induced an antiproliferative effect in ALT-positive U-2 OS cells with an IC50 of 8.8 µM.
Reduced U-2 OS cell viability to ~60% at 6.75 µM (compared to ~100% for telomerase-positive SJSA-1 cells).
Reduced U-2 OS cell viability to near 0% at 12.5 µM (compared to ~60% for SJSA-1 cells).
Showed minimal effect on cell viability when using the non-binding control tP4-nb-CPP12 at all tested concentrations.
Molecular Weight

2888.38

Formula

C145H199N39O25
Sequence

Ac-His-Phe-Lys-Leu-Tyr-Trp-Pro-Pro-Phe-Leu-Gly-Ser-Cyclo(Phe-{d-Phe}-{2-Nal}-Arg-{d-Arg}-Arg-{d-Arg}-Gln) (Disulfide bridge: Phe13-Gln20)
Sequence Shortening

Ac-HFKLYWPPFLGS-Cyclo(F-{d-Phe}-{2-Nal}-R-{d-Arg}-R-{d-Arg}-Q) (Disulfide bridge: Phe13-Gln20)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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tP4-CPP12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

tP4-CPP12DNA/RNA SynthesisALT-driven cancersRMI1/2 heterodimerFANCM-RMI interaction sitetelomerase-positive SJSA-1 cellsFANCM-RMI protein-protein interactionU-2 OS osteosarcoma cellsα-chymotrypsinALT-positive osteosarcoma cellsInhibitorinhibitorinhibit

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