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Cat. No.: HY-P11841

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tP4-CPP12

tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC₅₀ of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma.

For research use only. We do not sell to patients.

Formula: C₁₄₅H₁₉₉N₃₉O₂₅
Molecular Weight:2888.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

tP4-CPP12 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

tP4-CPP12 (6.75-12.5 µM, serial dilutions; 72 h) selectively induces antiproliferative effects in ALT-positive U-2 OS osteosarcoma cells with an IC₅₀ of 8.8 µM, with a more pronounced effect than on telomerase-positive SJSA-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

ALT-positive osteosarcoma U-2 OS cells, telomerase-positive osteosarcoma SJSA-1 cells
Concentration:

6.75 and 12.5 µM
Incubation Time:

72 h
Result:

Induced an antiproliferative effect in ALT-positive U-2 OS cells with an IC₅₀ of 8.8 µM.
Reduced U-2 OS cell viability to ~60% at 6.75 µM (compared to ~100% for telomerase-positive SJSA-1 cells).
Reduced U-2 OS cell viability to near 0% at 12.5 µM (compared to ~60% for SJSA-1 cells).
Showed minimal effect on cell viability when using the non-binding control tP4-nb-CPP12 at all tested concentrations.

Chemical Information

Molecular Weight 2888.38
Formula C₁₄₅H₁₉₉N₃₉O₂₅
Sequence

Ac-His-Phe-Lys-Leu-Tyr-Trp-Pro-Pro-Phe-Leu-Gly-Ser-Cyclo(Phe-{d-Phe}-{2-Nal}-Arg-{d-Arg}-Arg-{d-Arg}-Gln) (Disulfide bridge: Phe13-Gln20)
Sequence Shortening

Ac-HFKLYWPPFLGS-Cyclo(F-{d-Phe}-{2-Nal}-R-{d-Arg}-R-{d-Arg}-Q) (Disulfide bridge: Phe13-Gln20)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alcock LJ, et al. Cell-Active Peptide Inhibitors of the FANCM-RMI Interaction. Journal of medicinal chemistry. 2025 Nov 27;68(22):24672-24683. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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tP4-CPP12

All DNA/RNA Synthesis Isoforms