3128034-48-7
Chemical Structure
tP4-CPP12
- CAS No.: 3128034-48-7
- Formula:C145H199N39O25
- Molecular Weight:2888.38
InChIKey: HFHGYNLWPWKAOB-VBZWISEXSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CO)C(NCCCC[C@@H](C(N)=O)NC(CC[C@H]3C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N3)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC4=CC=CC5=C4C=CC=C5)=O)CC6=CC=CC=C6)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)[C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@H](NC([C@@H](NC(C)=O)CC9=CN=CN9)=O)CC%10=CC=CC=C%10)=O)=O)=O)CC%11=CC=C(C=C%11)O)=O)CC%12=CNC%13=CC=CC=C%12%13
Biological Activity: tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma[1].
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tP4-CPP12 | tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma. | |||||||||||||||||||||
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