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Results for "

RNA polymerization

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Biochemical Assay Reagents

2

MCE Kits

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W134327A
    DEAE-dextran (MW 500000)

    Diethylaminoethyl dextran (MW 500000)

    		 Biochemical Assay Reagents Others
    DEAE-Dextran (MW 500000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds and modified with diethylaminoethyl (DEAE) groups. DEAE-Dextran is a cationic molecule that can be used as a transfection reagent to deliver nucleic acids such as DNA or RNA into cells. Its positive charge interacts with negatively charged cell membranes, facilitating the uptake of nucleic acids. DEAE-Dextran can also be used as an ion-exchange chromatography resin, allowing the separation and purification of biomolecules based on their charge.
    DEAE-dextran (MW 500000)
  • HY-128854
    Dimethyl biphenyl-4,4'-dicarboxylate
    1 Publications Verification

    		 Biochemical Assay Reagents JAK STAT IFNAR DNA/RNA Synthesis HBV Infection Metabolic Disease
    Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B .\n
    Dimethyl biphenyl-4,4'-dicarboxylate
  • HY-159067
    DEAE-dextran, MW 500000 hydrochloride

    DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride

    		 Biochemical Assay Reagents Cancer
    DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .
    DEAE-dextran, MW 500000 hydrochloride
  • HY-W024881
    Potassium 2,3,3-trimethylindole-5-sulfonate

    2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt

    		 Drug Intermediate Others
    Potassium 2,3,3-trimethylindole-5-sulfonate (2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt) is an indole derivative containing a sodium sulfonate group and is commonly used as a key intermediate in dye synthesis. Potassium 2,3,3-trimethylindole-5-sulfonate can be coupled to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via the sulfonyl substituent .
    Potassium 2,3,3-trimethylindole-5-sulfonate
  • HY-168473
    13-TP

    		SARS-CoV DNA/RNA Synthesis Infection
    13-TP is an inhibitor of SARS-CoV-2. 13-TP effectively inhibits the SARS-CoV-2 central replication transcription complex (C-RTC, nsp12-nsp7-nsp82) catalyzed in vitro RNA synthesis. 13-TP completely inhibits the RdRp polymerization activity. 13-TP blocks the full extension of some of the primer RNA .
    13-TP
  • HY-181778
    RdRP-IN-10

    		SARS-CoV DNA/RNA Synthesis Infection
    RdRP-IN-10 is a SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor with an IC50 value of 5.78 μM. RdRP-IN-10 forms covalent binds with SARS-CoV-2 nsp8 Cys114, disrupts nsp8-nsp12 stabilizing interactions. RdRP-IN-10 inhibits SARS-CoV-2 RdRp-mediated RNA polymerization without interfering with RNA-RdRp complex binding. RdRP-IN-10 exerts antiviral effects in cellular models. RdRP-IN-10 can be used for the research of SARS-CoV-2 infection .
    RdRP-IN-10

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