3099256-57-9
Chemical Structure
RdRP-IN-10
- CAS No.: 3099256-57-9
- Formula:C21H20Cl3N3O4
- Molecular Weight:484.76
InChIKey: OGJXMDFXHMMYST-UHFFFAOYSA-N
SMILES: CC(CC(N1C2=CC=C(C=C2N=C1C3=CC(Cl)=CC(Cl)=C3O)NC(CCl)=O)C(O)=O)C
Biological Activity: RdRP-IN-10 is a SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor with an IC50 value of 5.78 μM. RdRP-IN-10 forms covalent binds with SARS-CoV-2 nsp8 Cys114, disrupts nsp8-nsp12 stabilizing interactions. RdRP-IN-10 inhibits SARS-CoV-2 RdRp-mediated RNA polymerization without interfering with RNA-RdRp complex binding. RdRP-IN-10 exerts antiviral effects in cellular models. RdRP-IN-10 can be used for the research of SARS-CoV-2 infection[1].
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RdRP-IN-10 | RdRP-IN-10 is a SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor with an IC50 value of 5.78 μM. RdRP-IN-10 forms covalent binds with SARS-CoV-2 nsp8 Cys114, disrupts nsp8-nsp12 stabilizing interactions. RdRP-IN-10 inhibits SARS-CoV-2 RdRp-mediated RNA polymerization without interfering with RNA-RdRp complex binding. RdRP-IN-10 exerts antiviral effects in cellular models. RdRP-IN-10 can be used for the research of SARS-CoV-2 infection. | |||||||||||||||||||||
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