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Cat. No.: HY-181778

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RdRP-IN-10

RdRP-IN-10 is a SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor with an IC₅₀ value of 5.78 μM. RdRP-IN-10 forms covalent binds with SARS-CoV-2 nsp8 Cys114, disrupts nsp8-nsp12 stabilizing interactions. RdRP-IN-10 inhibits SARS-CoV-2 RdRp-mediated RNA polymerization without interfering with RNA-RdRp complex binding. RdRP-IN-10 exerts antiviral effects in cellular models. RdRP-IN-10 can be used for the research of SARS-CoV-2 infection.

For research use only. We do not sell to patients.

CAS No.: 3099256-57-9
Formula: C₂₁H₂₀Cl₃N₃O₄
Molecular Weight:484.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

RdRP-IN-10 Chemical Structure

CAS No.: 3099256-57-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

In Vitro

RdRP-IN-10 (Compound 4) potently inhibits the SARS-CoV-2 nsp7/8/12 RdRp complex with an IC₅₀ of 5.78 μM^[1].
RdRP-IN-10 shows moderate antiviral activity in cellular models with an EC₅₀ of 87 μM^[1].
RdRP-IN-10 (20 μM) relies on covalent binding to Cys114 of nsp8 for inhibitory activity against the SARS-CoV-2 nsp7/nsp8/nsp12 RdRp complex, as activity is severely reduced against the nsp8^C114S mutant but preserved against the nsp8^C142S mutant^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3099256-57-9
Molecular Weight 484.76
Formula C₂₁H₂₀Cl₃N₃O₄
SMILES

CC(CC(N1C2=CC=C(C=C2N=C1C3=CC(Cl)=CC(Cl)=C3O)NC(CCl)=O)C(O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li L, et al. Fusion Strategy of DNA-Encoded Libraries Drives Discovery of Allosteric Inhibitors of SARS-CoV‑2 RdRp. JACS Au. 2026;6(2):1370-1381. Published 2026 Jan 23. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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RdRP-IN-10

All DNA/RNA Synthesis Isoforms