1 Result for "

Rhamnocitrin (Standard)

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Rhamnocitrin (Standard)" in MCE Product Catalog:

Rhamnocitrin (Standard)
Rhamnocitrin (Standard)
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Cat. No.: HY-N1353R
CAS No.: 569-92-6
Category:  

Flavonols other families Flavonoids Phenols Polyphenols Plants

Target:  

Reference Standards Others p38 MAPK

Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
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