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Results for "

SLC6A19

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156682
    JNT-517

    		Amino acid Transporter Metabolic Disease
    JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU) .
    JNT-517
  • HY-B1274
    Cinromide
    2 Publications Verification

    trans-3-Bromo-N-ethylcinnamamide

    		 Amino acid Transporter Neurological Disease Metabolic Disease
    Cinromide is an anticonvulsant agent. Cinromide inhibits epithelial neutral amino acid transporter B 0AT1 (SLC6A19) with an IC50 of 0.5 μM .
    Cinromide
  • HY-158161
    SLC6A19-IN-1

    		Amino acid Transporter Metabolic Disease
    SLC6A19-IN-1 is a potent and highly selective inhibitor and transport corrector of human SLC6A19 (IC50=47 nM). Furthermore, at a concentration of 35 μM, SLC6A19-IN-1 exhibits no activity against SLC1A5, SLC7A5, or SLC6A8. SLC6A19-IN-1 is applicable to research on phenylketonuria (PKU) and hyperphenylalaninemia. SLC6A19-IN-1 is also suitable for studies related to various metabolic disorders, including tyrosinemia, maple syrup urine disease, urea cycle disorders, and hyperammonemia .
    SLC6A19-IN-1
  • HY-162864
    JX237

    		Amino acid Transporter Metabolic Disease
    JX237 is an inhibitor of the epithelial neutral amino acid transporter B 0AT1 (SLC6A19) with an IC50 value of 31 nM. SLC6A19 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B 0AT1, JX237 can be used for the study of disorders of amino acid metabolism .
    JX237
  • HY-179107
    SLC6A19-IN-3

    		Amino acid Transporter Metabolic Disease
    SLC6A19-IN-3 (Compound 83-P1-P2) is a potent, selective and orally active SLC6A19 inhibitor with an IC50 of 28 nM. SLC6A19-IN-3 can block SLC6A19-mediated transmembrane transport of phenylalanine, reducing intestinal absorption of phenylalanine from food and renal tubular reabsorption of phenylalanine. SLC6A19-IN-3 can be used for the research of metabolic disease, such as phenylketonuria .
    SLC6A19-IN-3
  • HY-176873
    SLC6A19-IN-2

    		Amino acid Transporter Metabolic Disease
    SLC6A19-IN-2 (Example 4) is a potent SLC6A19 inhibitor with an IC50 of 14 nM. SLC6A19-IN-2 can be used for the study of metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD) and phenylketonuria (PKU) .
    SLC6A19-IN-2
  • HY-RS13305
    SLC6A19 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SLC6A19 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC6A19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SLC6A19 Human Pre-designed siRNA Set A
    SLC6A19 Human Pre-designed siRNA Set A
  • HY-179689
    SLC6A19-IN-5

    		Amino acid Transporter Metabolic Disease
    SLC6A19-IN-5 (Example 25) is a SLC6A19 inhibitor with an IC50 of 11 nM. SLC6A19-IN-5 can be used for research on diseases related to abnormal amino acid metabolism, amino acid transport, and/or amino acid levels .
    SLC6A19-IN-5
  • HY-179581
    SLC6A19-IN-4

    		Amino acid Transporter Metabolic Disease
    SLC6A19-IN-4 is an allosteric-competitive and orally active B 0AT1 inhibitor. SLC6A19-IN-4 inhibits both human and mouse B 0AT1 with IC50 values of 513 nM and 295 nM, respectively. SLC6A19-IN-4 exhibits excellent metabolic stability. SLC6A19-IN-4 significantly increases urinary phenylalanine (Phe) excretion and reduces plasma Phe levels through dual inhibition of B 0AT1 in both the intestine (reducing absorption) and kidney (promoting excretion) in vivo. SLC6A19-IN-4 can be used for phenylketonuria (PKU) and other disorders involving SLC6-family transporters research .
    SLC6A19-IN-4

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