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Results for "

SMC3

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS18370
    Smc3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Smc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Smc3 Mouse Pre-designed siRNA Set A
    Smc3 Mouse Pre-designed siRNA Set A
  • HY-RS13419
    SMC3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SMC3 Human Pre-designed siRNA Set A contains three designed siRNAs for SMC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SMC3 Human Pre-designed siRNA Set A
    SMC3 Human Pre-designed siRNA Set A
  • HY-RS24849
    Smc3 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Smc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Smc3 Rat Pre-designed siRNA Set A
    Smc3 Rat Pre-designed siRNA Set A
  • HY-158308
    HDAC6-IN-41

    		HDAC Cancer
    HDAC6-IN-41 (Compound E24) is a selective inhibitor for histone deacetylase 6 (HDAC6), with IC50 of 14 and 422 nM, for HDAC6 and HDAC8, respectively. HDAC6-IN-41 upregulates the acetylation of α-tubulin and histone site SMC3 .
    HDAC6-IN-41
  • HY-181979
    HDAC8-IN-15

    		HDAC Apoptosis Neurological Disease Cancer
    HDAC8-IN-15 is a selective HDAC8 inhibitor with an IC50 of 0.40 μM. HDAC8-IN-15 increases the acetylation level of the HDAC8 substrate SMC3 without altering the total protein level of SMC3. HDAC8-IN-15 reduces cancer cell viability, inhibits colony formation, slows cell migration, induces apoptosis, and causes cell cycle arrest at the SubG1 phase. HDAC8-IN-15 can be used in studies related to neuroblastoma .
    HDAC8-IN-15
  • HY-181024
    PROTAC HDAC8 Degrader-4

    		PROTACs HDAC Cancer
    PROTAC HDAC8 Degrader-3 (Compound BP6) is an efficient, selective and low-toxicity HDAC8 PROTAC degrader with a DC50 of 80 nM. PROTAC HDAC8 Degrader-3 exhibits IC50 of PROTAC for HDAC8 and CRBN of 0.26 and 30 μM respectively. PROTAC HDAC8 Degrader-3 increases the level of Ac-SMC3, stabilizes p53 and sensitizes targeted reagents (such as Idasanutlin (HY-15676)), demonstrating its great potential in combination therapy .
    PROTAC HDAC8 Degrader-4
  • HY-150772
    Tubulin/HDAC-IN-1

    		Microtubule/Tubulin HDAC Apoptosis Mitochondrial Metabolism Cancer
    Tubulin/HDAC-IN-1 is a dual tubulin and HDAC-IN-1 inhibitor through CH/π interaction with tubulin and hydrogen bond interaction with HDAC8. Tubulin/HDAC-IN-1 inhibits tubulin polymerization and selectively inhibits HDAC8 (IC50: 150 nM). Tubulin/HDAC-IN-1 has cytotoxicity against various human cancer cells, also arrests cell cycle in the G2/M phase and induces cell apoptosis. Tubulin/HDAC-IN-1 can be used in the research of hematologic and solid tumors such as neuroblastoma, leukemia .
    Tubulin/HDAC-IN-1
  • HY-182035
    HDAC8-IN-16

    		HDAC Apoptosis Cancer
    HDAC8-IN-16 is a selective histone deacetylase 8 (HDAC8) inhibitor with an IC50 of 0.16 μM. HDAC8-IN-16 induces cell apoptosis, triggers G2/M phase cell cycle arrest, and moderately inhibits cancer cell proliferation. HDAC8-IN-16 is applicable to relevant research on colorectal cancer .
    HDAC8-IN-16

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