SMC3 Antibody (YA7398)

Art. -Nr.: HY-P87713: Data Sheet User Guide for Antibodies
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Technical Support

SMC3 Antibody (YA7398) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to SMC3.

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

SMC3 Antibody (YA7398) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to SMC3.

Host

Rabbit

Clonality

Monoclonal,Recombinant

Molekulargewicht

Predicted band size: 142 kDa;

Observed band size: 142 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9UQE7

Immunogen

The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
WB WB: Western Blot	1:2000-1:10000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-1:20000

Sensitivity	Endogenous	Reinheit	Protein A affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG,Kappa

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement

Subcellular Localization：Nucleus,Chromosome,Chromosome, centromere

Isoforms & Post-Translational Modification：Q9UQE7: 1217 amino acids, molecular weight 141542 Da.

Subunit：Forms a heterodimer with SMC1A or SMC1B in cohesin complexes (PubMed:22628566)

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/hct-116-cell.html [Content Brief]