Search Result

Results for "

SP3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) Aldose Reductase (1) Drug Metabolite (1) FKBP (2) Interleukin Related (1) ROR (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS13606

SP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SP3 Human Pre-designed siRNA Set A contains three designed siRNAs for SP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SP3 Human Pre-designed siRNA Set A SP3 Human Pre-designed siRNA Set A

HY-161794A

SP3N hydrochloride	FKBP	Cancer
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCF ^FBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer .

HY-RS25079

Sp3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sp3 Rat Pre-designed siRNA Set A Sp3 Rat Pre-designed siRNA Set A

HY-RS18594

Sp3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sp3 Mouse Pre-designed siRNA Set A Sp3 Mouse Pre-designed siRNA Set A

HY-161795

SP3CHO	Drug Metabolite	Cancer
SP3CHO is an active metabolite generated by the metabolism of SP3N in cell culture by the action of amine oxidase. SP3CHO can induce polyubiquitination of specific proteins by recruiting the SCFFBXO22 E3 ligase complex. SP3CHO can be used in cancer therapy research .

HY-161794

SP3N	FKBP	Cancer
SP3N is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCF ^FBXO22 ligase for FKBP12 degradation. SP3N may be used in research for cancer .

HY-173132

AKR1Cs-IN-1	Aldose Reductase	Cancer
AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and *SP3* pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC₅₀ values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, *AKR1C3, and AKR1C4*, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer .

HY-180813

RORγ-IN-3	ROR Interleukin Related	Inflammation/Immunology
RORγ-IN-3 (Compound 21) is a potent and highly selective RORγ inhibitor with an EC₅₀ of 84 nM. RORγ-IN-3 can effectively inhibit the production of IL-17, with an IC₅₀ value of 1.0 μM. RORγ-IN-3 can be used for the study of autoimmune diseases .

HY-123732

CRT0083914	17β-HSD	Cancer
CRT0083914 is a subtype-selective non-carboxylate inhibitor of *AKR1C3*. CRT0083914 is applicable to the research of colon cancer .

Cat. No.	Product Name

HY-L0104V

UORSY New Generation Screening Library	1,900,000 compounds
UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.

UORSY New Generation Screening Library

1,900,000 compounds

UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.

SP3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SP3 Human Pre-designed siRNA Set A contains three designed siRNAs for SP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sp3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sp3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.