1 Result for "

Sul 121

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Sul 121" in MCE Product Catalog:

Cat. No.: HY-123461
CAS No.: 1541170-25-5
Target:  

NF-κB

Research Areas:  

Inflammation/Immunology

Sul-121 hydrochloride is a novel compound with anti-oxidative capacity that effectively inhibits airway inflammation and hyperresponsiveness (AHR) in experimental models of chronic obstructive pulmonary disease (COPD). Sul-121 hydrochloride prevents lipopolysaccharide-induced airway neutrophilia and AHR in a dose-dependent manner. Sul-121 hydrochloride also demonstrates the ability to reduce oxidative stress markers in human airway smooth muscle cells. Sul-121 hydrochloride inhibits nuclear translocation of the NF-κB subunit, p65, thereby diminishing pro-inflammatory cytokine release.
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