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TREM2-IN-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160421
    TREM2-IN-1

    		Apoptosis Inflammation/Immunology Cancer
    TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 + and CX3CR1 + immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells .
    TREM2-IN-1
  • HY-174369
    TREM2 agonist-3

    		TREM receptor Syk Neurological Disease
    TREM2 agonist-3 (Compound 4i) is a TREM2 agonist with a KD value of 19.0 µM. The KD value of TREM2 agonist-3 for TREM1 is 39.8 µM. TREM2 agonist-3 induces an increase in phosphorylated SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases associated with TREM2 dysfunction .
    TREM2 agonist-3
  • HY-182756
    TREM2 modulator-1

    		TREM receptor Neurological Disease
    TREM2 modulator-1 is a TREM2 modulator with an EC50 categorized as A and Emax of ++, and can be found in relevant research contexts. TREM2 modulator-1 modulates Triggering Receptor Expressed on Myeloid Cells 2. TREM2 modulator-1 can be used for the research of neurodegenerative diseases .
    TREM2 modulator-1

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