2459994-71-7
Chemical Structure
GPR34 agonist 1
- CAS No.: 2459994-71-7
- Formula:C30H36NO11P
- Molecular Weight:617.58
InChIKey: PWIBLZZVGUIXAU-SXOMAYOGSA-N
SMILES: OC([C@@H](N)COP(O[C@H](COCC)COC(CCC(C=CC=C1)=C1OCC2=CC(OC3=CC=CC=C3)=CC=C2)=O)(O)=O)=O
Biological Activity: GPR34 agonist 1 is a G-protein coupled receptor 34 agonist that enhances fibrillar Aβ uptake in mouse primary microglia with an EC50 of 5 nM[1].GPR34 agonist 1 selectively activates Gi/o-coupled GPR34, reduces intracellular cyclic adenosine monophosphate levels, and requires functional TREM2 signaling[1].GPR34 agonist 1 induces microglial Aβ fibril phagocytosis and chemotaxis, enhances microglial uptake and clearance of amyloid β fibrils, and increases microglial Aβ fibril uptake in vivo and in human induced pluripotent stem cell-derived microglia[1].GPR34 agonist 1 can be used for the research of Alzheimer disease[1].
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GPR34 agonist 1 | GPR34 agonist 1 is a G-protein coupled receptor 34 agonist that enhances fibrillar Aβ uptake in mouse primary microglia with an EC50 of 5 nM.GPR34 agonist 1 selectively activates Gi/o-coupled GPR34, reduces intracellular cyclic adenosine monophosphate levels, and requires functional TREM2 signaling.GPR34 agonist 1 induces microglial Aβ fibril phagocytosis and chemotaxis, enhances microglial uptake and clearance of amyloid β fibrils, and increases microglial Aβ fibril uptake in vivo and in human induced pluripotent stem cell-derived microglia.GPR34 agonist 1 can be used for the research of Alzheimer disease. | |||||||||||||||||||||
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