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TZ1104

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-183073
    TZ1104

    		Cancer
    TZ1104 is a PROTAC-based CDK7 degrader, with a DC50 of 0.88 nM. TZ1104 forms a ternary complex with VHL E3 ligase and CDK7 to trigger proteasome-dependent CDK7 degradation, destabilizing the CDK7-cyclin H-MAT1 complex. TZ1104 suppresses phosphorylation of RNA polymerase II CTD Ser5, CDK1 Thr161, and CDK2 Thr160. TZ1104 activates the p53-p21 axis and suppresses oncogenic Myc signaling. TZ1104 induces cell cycle arrest, apoptosis, and differentiation of acute leukemia cells. TZ1104 can be used for the research of acute leukemia .
    TZ1104
  • HY-183083
    CDK7 ligand 3-CO-C5-COOH

    		Target Protein Ligand-Linker Conjugates CDK Others
    CDK7 ligand 3-CO-C5-COOH (compound 7) is a conjugate of CDK7 ligand and linker, which can be used for the synthesis of PROTAC TZ1104 (HY-183073) .
    CDK7 ligand 3-CO-C5-COOH

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