3 Results for "

TcTS

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "TcTS" in MCE Product Catalog:

Cat. No.: HY-177434
CAS No.: 2873366-83-5
Synonyms: Precem-TcT; M 9140
Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC .
loading...
    loading...
Cat. No.: HY-172951
Target:  

Parasite

Research Areas:  

Infection

Antitrypanosomal agent 23 is an antitrypanosomal agent. Antitrypanosomal agent 23 has activity against intracellular amastigotes of T. cruzi in LLC-MK2 and C2C12 cells (IC50: 0.10 and 0.11 μM). Antitrypanosomal agent 23 is a weak inhibitor of Recombinant trans-sialidase from T. cruzi (TcTS) (IC50: 1.1 mM) .
loading...
    loading...
Cat. No.: HY-W040126
CAS No.: 67262-86-6
Synonyms: GalNAcα-O-Ser
Target:  

Parasite

Research Areas:  

Infection

Tn Antigen (Tn Epitope) (Compound 1) is a Trypanosoma cruzi trans-sialidase (TcTS) inhibitor with inhibition rate of 57% at 1 mM. Tn Antigen shows anti-trypanosomal activity with an IC50 of >0.5 mM. Tn Antigen can be used for the research of Chagas’ disease .
loading...
    loading...