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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
Transition state mimic
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "Transition state mimic" in MCE Product Catalog:
Cat. No.: HY-144741
CAS No.: 2872604-91-4
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Research Areas:
BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC50 of 1.2 µM .
Cat. No.: HY-144739
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BACE1-IN-8 (compound 70b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC50 of 3.9 µM .
Cat. No.: HY-182301
CAS No.: 112227-15-3
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CP 71362 is a renin inhibitor, a highly potent substrate-analog transition state mimic with antihypertensive properties. CP 71362 exhibits significant inhibitory activity against plasma renin from rats, dogs, and humans (IC50 values are 3 nM, 0.0033 nM, and 20 nM, respectively). CP 71362 reduces the mean arterial pressure of anesthetized and conscious sodium-depleted animals in a dose-dependent manner, and has pharmacokinetic characteristics of rapid elimination and short duration of action. CP 71362 can be used in research related to hypertension and congestive heart failure .
Cat. No.: HY-W1060365
CAS No.: 2089-12-5
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4-((Aminooxy)methyl)phenol is an Indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor with a human IC50 of 61 μM. 4-((Aminooxy)methyl)phenol inhibits IDO1 catalytic activity and acts as a structural mimic of the enzyme's alkylperoxy transition or intermediate state. 4-((Aminooxy)methyl)phenol can be used for the research of cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
