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Trijuganone C

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-N8617
    Trijuganone C

    		DNA/RNA Synthesis Caspase PARP Bcl-2 Family Mitochondrial Metabolism Apoptosis Cancer
    Trijuganone C is a tanshinone-type diterpenoid compound. Trijuganone C can be isolated from the roots of Salvia miltiorrhiza Bunge. Trijuganone C induces chromatin condensation, DNA fragmentation, activation of Caspase-3, -8 and -9, as well as cleavage of PARP. Trijuganone C activates Bid and Bax, leading to loss of mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytosol. Trijuganone C exerts antiproliferative effects through Apoptosis induction mediated by Mitochondrial dysfunction and Caspase activation. Trijuganone C exhibits significant antiproliferative activity against leukemia cells and colon cancer cells .
    Trijuganone C

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