82 Results for "

Trop

" in MedChemExpress (MCE) Product Catalog:
Products (82)

82 Results for "Trop" in MCE Product Catalog:

  • Targets Recommended:
11
Sacituzumab govitecan
Sacituzumab govitecan
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11 Publications Verification
Cat. No.: HY-132254
CAS No.: 1491917-83-9
Purity:  99.13%
Synonyms: IMMU-132
Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. The antibody portion is Sacituzumab (HY-P99045), and the drug-linker conjugate for ADC is CL2A-SN-38 (HY-128946). Sacituzumab govitecan shows anticancer activity .
11
Sacituzumab govitecan (solution)
Sacituzumab govitecan (solution)
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11 Publications Verification
Cat. No.: HY-132254A
CAS No.: 1491917-83-9
Purity:  96.61%
Synonyms: IMMU-132 (solution)
Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. The antibody portion is Sacituzumab (HY-P99045), and the drug-linker conjugate for ADC is CL2A-SN-38 (HY-128946). Sacituzumab govitecan shows anticancer activity .
8
Sacituzumab
Sacituzumab
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8 Cited Publications
Cat. No.: HY-P99045
CAS No.: 1796566-95-4
Synonyms: HRS7; hRS7

Target:  

ADC Antibodies TROP2

Research Areas:  

Cancer

Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
3
EpCAM/TROP1 Protein, Human (HEK293, His)
EpCAM/TROP1 Protein, Human (HEK293, His)
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3 Cited Publications
Cat. No.: HY-P70154
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuEpithelial cell adhesion molecule/EpCAM, His; Epithelial Cell Adhesion Molecule; Ep-CAM; Adenocarcinoma-Associated Antigen; Cell Surface Glycoprotein Trop-1; Epithelial Cell Surface Antigen; Epithelial Glycoprotein; EGP; Epithelial Glycoprotein 314; EGP314; hEGP314; KSA; Tumor-Associated Calcium Signa
Species:  
Human
Source:  
HEK293
2
Datopotamab deruxtecan (solution)
Datopotamab deruxtecan (solution)
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2 Cited Publications
Cat. No.: HY-141598
CAS No.: 2238831-60-0
Purity:  99.54%
Synonyms: DS-1062 (solution); Dato-DXd (solution)
Datopotamab deruxtecan (DS-1062) solution is a TROP2-targeted antibody-drug conjugate (ADC) with human TROP2 Kd of 0.74 nmol/L. Datopotamab deruxtecan solution consists of the antibody Datopotamab (HY-P99843) and the toxic molecule-linker conjugate Deruxtecan (HY-13631E). Datopotamab deruxtecan solution binds TROP2, triggers internalization and lysosomal trafficking and releases DXd topoisomerase I inhibitor payload. Datopotamab deruxtecan solution disrupts DNA function, induces DNA damage, apoptosis, and bystander killing of tumor microenvironment cells. Datopotamab deruxtecan solution can be used in research related to triple-negative breast cancer, gastric cancer, and non-small cell lung cancer .
2
TROP-2 Protein, Human (248a.a, HEK293, His)
TROP-2 Protein, Human (248a.a, HEK293, His)
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2 Cited Publications
Cat. No.: HY-P70457
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tumor-associated calcium signal transducer 2; Membrane component chromosome 1 surface marker 1; Cell surface glycoprotein Trop-2; TACSTD2; Trop2
Species:  
Human
Source:  
HEK293
1
Datopotamab
Datopotamab
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1 Cited Publications
Cat. No.: HY-P99843
CAS No.: 2267989-53-5
Datopotamab (CDP7657) is a humanized anti trophoblast cell surface antigen 2 (TROP2) antibody. Datopotamab can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab can be used in the study of triple negative breast cancer and non-small cell lung cancer .
1
CL2-SN-38
CL2-SN-38
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1 Cited Publications
Cat. No.: HY-126350
CAS No.: 1036969-20-6
Purity:  99.14%
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

CL2-SN-38 is a cleavable linker-based agent-Linker conjugate, it can conjugate with the anti-Trop-2-humanized antibody hRS7. CL2-SN-38 can be used for the reasearch of cancer .
Sacituzumab tirumotecan
Sacituzumab tirumotecan
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Cat. No.: HY-164789
CAS No.: 2768350-77-0
Synonyms: SKB264; MK-2870
Sacituzumab tirumotecan is an antibody-drug conjugate and TROP2-directed, topoisomerase I inhibitor payload-delivering agent, with a TROP2 EC50 of 2.787 ng/ml, TROP2 Ka of 0.3083 nM, and topoisomerase I IC50 of 0.7 μmol/L. Sacituzumab tirumotecan can be used for the research of metastatic triple-negative breast cancer, and metastatic non-small cell lung cancer .
Pumitamig
Pumitamig
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Cat. No.: HY-P991097
Synonyms: PM-8002; BNT-327

Target:  

VEGFR PD-1/PD-L1

Research Areas:  

Cancer

Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy .
Sacituzumab (powder)
Sacituzumab (powder)
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Cat. No.: HY-P99045A
CAS No.: 1796566-95-4

Target:  

ADC Antibodies TROP2

Research Areas:  

Cancer

Sacituzumab (powder) is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab (powder) demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab (powder) can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
TL033
TL033
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Cat. No.: HY-147340
CAS No.: 2356230-22-1
Synonyms: Tirumotecan
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

TL033 is a drug-Linker conjugates for ADC. TL033 contains a linker and bioactive small molecule toxins. TL033 can conjugate with Sacituzumab antibody (anti Trop-2) for synthesizing BT001021. BT001021 has anti-cancer activities against various cancers, such as breast cancer, non-small cell lung cancer (NSCLC), gastric cancer .
TL033 TFA
TL033 TFA
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Cat. No.: HY-147340A
CAS No.: 2746343-70-2
Synonyms: Tirumotecan TFA
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

TL033 TFA is a drug-Linker conjugates for ADC. TL033 TFA contains a linker and bioactive small molecule toxins. TL033 TFA can conjugate with Sacituzumab antibody (anti Trop-2) for synthesizing BT001021. BT001021 has anti-cancer activities against various cancers, such as breast cancer, non-small cell lung cancer (NSCLC), gastric cancer .
Anti-TROP2 Antibody
Anti-TROP2 Antibody
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Cat. No.: HY-P991372
Synonyms: RN927C antibody

Target:  

TROP2

Research Areas:  

Cancer

Anti-TROP2 Antibody (RN927C antibody) is a human monoclonal antibody targeting Trop-2. Anti-TROP2 Antibody exerts in vitro inhibitory effects on a variety of tumor cell lines. Anti-TROP2 Antibody exhibits anti-tumor activity in mouse pancreatic PDX, ovarian PDX, lung PDX and triple-negative breast cancer (TNB) PDX models. Anti-TROP2 Antibody can be used for research on pancreatic cancer, ovarian cancer, lung cancer and triple-negative breast cancer .
Varsetatug
Varsetatug
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Cat. No.: HY-P991723
CAS No.: 3036004-28-8
Synonyms: CX-2051 antibody

Target:  

ADC Antibodies Transmembrane Glycoprotein

Research Areas:  

Cancer

Varsetatug (CX-2051 antibody) is a humanized IgG1κ monoclonal antibody inhibitor targeting EpCAM/TROP1/CD326. Varsetatug serves as the antibody component of the ADC compound CX-2051. It can be used in research on cancers including breast cancer, prostate cancer and ovarian cancer .
Oportuzumab
Oportuzumab
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Cat. No.: HY-P990642

Target:  

Transmembrane Glycoprotein

Research Areas:  

Inflammation/Immunology

Oportuzumab is a CHO-expressed humanized antibody that targets EpCAM/TROP1/CD326. Oportuzumab contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Oportuzumab can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
Anti-TROP-2 Antibody (Pr1E11)
Anti-TROP-2 Antibody (Pr1E11)
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Cat. No.: HY-P990827

Target:  

TROP2

Research Areas:  

Cancer

Anti-TROP-2 Antibody (Pr1E11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human TROP-2. Anti-TROP-2 Antibody (Pr1E11) specifically binds to TROP-2 with high affinity and shows low internalization activitv. Anti-TROP-2 Antibody (Pr1E11) can be used for the research of cancer, such as epithelial cancer and primary pancreatic cancer .
Gint4.T aptamer sodium
Gint4.T aptamer sodium
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Cat. No.: HY-160053
Target:  

PDGFR

Research Areas:  

Cancer

Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .
thioxo-Dxd
thioxo-Dxd
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Cat. No.: HY-178262A
CAS No.: 2806052-35-5
Target:  

ADC Payloads

Research Areas:  

Cancer

thioxo-Dxd is a Camptothecin (HY-16560) derivative. thioxo-Dxd can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. thioxo-Dxd can be used for research on tumors with high HER2 or TROP2 expression .
MC-GGFG-AM-(10NH2-11F-Camptothecin)
MC-GGFG-AM-(10NH2-11F-Camptothecin)
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Cat. No.: HY-156514
CAS No.: 2987938-97-4
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

MC-GGFG-AM-(10NH2-11F-Camptothecin) is an antibody drug conjugates (ADC). MC-GGFG-AM-(10NH2-11F-Camptothecin) binds to the anti-TROp-2 antibody sacituzumab via a hydrolysable pH-sensitive linker and has anti-tumor activity. MC-GGFG-AM-(10NH2-11F-Camptothecin) can be used for cancer research .
Assay Types