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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
Tz-IFDL
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "Tz-IFDL" in MCE Product Catalog:
Cat. No.: HY-D3369
CAS No.: 3114128-44-5
Target:
Research Areas:
Tz‑IFDL is a chemiluminescent probe for in vivo imaging of N‑methyl‑D‑aspartate receptors (NMDAR), which specifically binds to the NR2B subunit of NMDAR. Tz‑IFDL undergoes a bioorthogonal reaction with probe CL‑NC (HY-D3370), triggering molecular fragment release and chemiluminescence. The CL‑NC/Tz‑IFDL system composed of Tz‑IFDL exhibits a chemiluminescence emission wavelength of 710 nm. When combined with CL‑NC, Tz‑IFDL can be used for deep tissue imaging to distinguish NMDAR expression levels between Alzheimer's disease model mice and normal mice .
Cat. No.: HY-D3370
CAS No.: 3114128-41-2
Target:
Research Areas:
CL-NC is a chemiluminescent probe used for in vivo imaging of N-methyl-D-aspartate receptors (NMDARs), and its detection mechanism relies on bioorthogonal activation achieved via a tetrazine-triggered click-to-release reaction. The isonitrile group of CL-NC undergoes a click reaction with tetrazine, followed by hydrolysis and β-elimination to release a phenoxide anion, which induces the departure of adamantane and generates chemiluminescence. CL-NC has a maximum absorption wavelength of approximately 425 nm, a maximum fluorescence emission wavelength of approximately 670 nm, and a maximum chemiluminescence emission wavelength of 710 nm. When used in combination with Tz-IFDL (HY-D3369), an NMDAR ligand conjugated with tetrazine, CL-NC enables targeted imaging of NMDARs in living cells, as well as in the brain and spinal cord of living mice .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
