3114128-44-5
Chemical Structure
Tz-IFDL
- CAS No.: 3114128-44-5
- Formula:C38H49N7O3
- Molecular Weight:651.84
InChIKey: HFSVXAQWVKGTTF-OCKRADGESA-N
SMILES: OC(C=C1)=CC=C1[C@H]([C@@H](C)N2CCC(CC3=CC=CC=C3)CC2)NCCCCCCNC(OCC4=CC=C(C5=NN=C(C)N=N5)C=C4)=O
Biological Activity: Tz‑IFDL is a chemiluminescent probe for in vivo imaging of N‑methyl‑D‑aspartate receptors (NMDAR), which specifically binds to the NR2B subunit of NMDAR. Tz‑IFDL undergoes a bioorthogonal reaction with probe CL‑NC (HY-D3370), triggering molecular fragment release and chemiluminescence. The CL‑NC/Tz‑IFDL system composed of Tz‑IFDL exhibits a chemiluminescence emission wavelength of 710 nm. When combined with CL‑NC, Tz‑IFDL can be used for deep tissue imaging to distinguish NMDAR expression levels between Alzheimer's disease model mice and normal mice[1].
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Tz-IFDL | Tz‑IFDL is a chemiluminescent probe for in vivo imaging of N‑methyl‑D‑aspartate receptors (NMDAR), which specifically binds to the NR2B subunit of NMDAR. Tz‑IFDL undergoes a bioorthogonal reaction with probe CL‑NC (HY-D3370), triggering molecular fragment release and chemiluminescence. The CL‑NC/Tz‑IFDL system composed of Tz‑IFDL exhibits a chemiluminescence emission wavelength of 710 nm. When combined with CL‑NC, Tz‑IFDL can be used for deep tissue imaging to distinguish NMDAR expression levels between Alzheimer's disease model mice and normal mice. | |||||||||||||||||||||
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