1 Result for "

ULK100

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ULK100" in MCE Product Catalog:

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Cat. No.: HY-125199
CAS No.: 945377-65-1
Target:  

ULK Autophagy

Research Areas:  

Cancer

ULK-100 is a potent ULK1/ULK2 inhibitor, with IC50 values of 1.6 nM and 2.6 nM against human ULK1 and ULK2, respectively. ULK-100 reduces ULK1-mediated phosphorylation of Beclin 1 at Ser15, inhibits autophagy by targeting the ULK1 pathway, and also suppresses autophagy in tumor cells. ULK-100 enhances the sensitivity of tumor cells to nutrient deprivation. ULK-100 can be used in research on autophagy initiation and cancer .
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