945377-65-1
945377-65-1
Chemical Structure
ULK-100
- CAS No.: 945377-65-1
- Formula:C29H32F3N5O2S
- Molecular Weight:571.66
IUPAC Name: (S)-4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2-yl)thiophene-2-carboxamide
InChIKey: KYPQUQARPVLCEI-SANMLTNESA-N
SMILES: O=C(C1=CC(C2=C3N=CC(C4=CC=C(OCCN5CCCCC5)C=C4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F
Biological Activity: ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC50 value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma)[1].
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ULK-100 | ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC50 value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma). | |||||||||||||||||||||
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References
Keywords
