1 Result for "

Vernodalin

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Vernodalin" in MCE Product Catalog:

Vernodalin
Vernodalin
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Cat. No.: HY-N19029
CAS No.: 21871-10-3
Category:  

Terpenoids Asteraceae Vernonia cinerascens Diterpenoids Plants

Target:  

p38 MAPK PERK JNK Akt PI3K mTOR FAK MMP PAI-1 Reactive Oxygen Species (ROS) Caspase Bcl-2 Family Apoptosis VEGFR AMPK Parasite

Vernodalin is an orally active, cytotoxic sesquiterpene lactone with a Kd value of 9.55 μM for p38 MAPK. Vernodalin downregulates the expression of phosphorylated ERK, JNK, AKT, PI3K, mTOR, p38MAPK, FAK, MMP-2, MMP-9, and uPA, while upregulates the expression of TIMP-1 and TIMP-2. Vernodalin increases ROS production, upregulates the expression of Bax and caspase 3, downregulates the expression of Bcl-2, and induces apoptosis (apoptosis), oxidative stress response and cell cycle arrest. Vernodalin inhibits the proliferation, adhesion and metastasis of cancer cells. Vernodalin enhances the activity of VEGF-B, AMPK and eNOS signaling pathways. Vernodalin alleviates myocardial injury and restores hemodynamic parameters. Vernodalin inhibits the growth of Trypanosoma brucei rhodesiense. Vernodalin can be used in research related to various cancers including gastric cancer, colorectal cancer and lung cancer, as well as African human trypanosomiasis and myocardial infarction .
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