3 Results for "

aryl pentanamide

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "aryl pentanamide" in MCE Product Catalog:

Tetrahydropiperine
Tetrahydropiperine
0 Images
Cat. No.: HY-N4205
CAS No.: 23434-88-0
Category:  

Alkaloids Piperidine Alkaloids Piperaceae Plants Disease Research Fields Piper nigrum Linn. Cancer

Target:  

Cytochrome P450

Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs, and an activator of the PI3K/Akt/mTOR pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .
loading...
    loading...
View All Sizes
Tetrahydropiperine (Standard)
Tetrahydropiperine (Standard)
0 Images
Cat. No.: HY-N4205R
CAS No.: 23434-88-0
Category:  

Alkaloids Piperidine Alkaloids Piperaceae Plants Piper nigrum Linn.

Target:  

Reference Standards Cytochrome P450

Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine (HY-N4205). This product is intended for research and analytical applications. Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs, and an activator of the PI3K/Akt/mTOR pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .
loading...
    loading...
View All Sizes
2'-Hydroxy-5'-methylacetophenone (Standard)
2'-Hydroxy-5'-methylacetophenone (Standard)
0 Images
Cat. No.: HY-W100681R
CAS No.: 1450-72-2
Target:  

Drug Intermediate Reference Standards

Research Areas:  

Others

Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .
loading...
    loading...
View All Sizes
Assay Types