9 Results for "

black mamba

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "black mamba" in MCE Product Catalog:

Cat. No.: HY-P3269
CAS No.: 178805-91-9
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease

Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases[1].
loading...
    loading...
Cat. No.: HY-P1441
CAS No.: 1609937-15-6
Target:  

Sodium Channel

Research Areas:  

Others

Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation .
loading...
    loading...
Cat. No.: HY-P5863
Synonyms: Mamb-2
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Mambalgin-2 (Mamb-2) is an acid-sensitive ion channels (ASICs) inhibitor and a venom peptide. Mambalgin-2 can be obtained from the venom of the African black mamba. Mambalgin-2 can be used in the study of pain and neurological diseases .
loading...
    loading...
Cat. No.: HY-P5835
CAS No.: 189201-23-8
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

δ-Dendrotoxin is a K + channel blocker that can be obtained from the venom of the black mamba snake. δ-Dendrotoxin can be used in the study of neurological diseases .
loading...
    loading...
Cat. No.: HY-P705701
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Toxin MIT1; MIT 1; black mamba intestinal toxin 1; black mamba venom protein A
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P3269A
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease

Calciseptine TFA, a polypeptide found in black mamba venom, is a selcetive Cav1.2 L-type calcium channel inhibitor with an IC50 of 92 nM. Calciseptine TFA binds to the pore domain shoulder at repeats III and IV of Cav1.2, stabilizing an inactivated conformation. Calciseptine TFA exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine TFA can be used for the research of cardiovascular diseases .
loading...
    loading...
Cat. No.: HY-P71906
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PROK1; PK1; Prokineticin 1; Endocrine-Gland-Derived Vascular Endothelial Growth Factor; EG-VEGF; black mamba Toxin-Related Protein; mambakine; Prokineticin-1; EGVEGF; Endocrine Gland-Derived Vascular Endothelial Growth Factor; PRK1
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P74616
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PROK1; PK1; Prokineticin 1; Endocrine-Gland-Derived Vascular Endothelial Growth Factor; EG-VEGF; black mamba Toxin-Related Protein; mambakine; Prokineticin-1; EGVEGF; Endocrine Gland-Derived Vascular Endothelial Growth Factor; PRK1
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78016
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PROK1; PK1; Prokineticin 1; Endocrine-Gland-Derived Vascular Endothelial Growth Factor; EG-VEGF; black mamba Toxin-Related Protein; mambakine; Prokineticin-1; EGVEGF; Endocrine Gland-Derived Vascular Endothelial Growth Factor; PRK1
Species:  
Source:  
loading...
    loading...