14 Results for "

c-FLIP

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "c-FLIP" in MCE Product Catalog:

21
Guggulsterone
Guggulsterone
0 Images
21 Publications Verification
製品番号: HY-107738
CAS 番号: 95975-55-6
純度:  99.81%
別名: Z/E-Guggulsterone
Category:  

Triterpenes Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .
18
Amentoflavone
Amentoflavone
0 Images
18 Cited Publications
製品番号: HY-N0662
CAS 番号: 1617-53-4
別名: Didemethyl-ginkgetin
Category:  

Flavonoids Phenols Polyphenols Selaginellaceae Plants Disease Research Fields Selaginella tamariscina (P. Beauv.) Spring Biflavones Cancer

Target:  

Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor

Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .
7
Jaceosidin
Jaceosidin
0 Images
7 Cited Publications
製品番号: HY-N0831
CAS 番号: 18085-97-7
Category:  

Laburnum anagyroides Medic. Flavonoids Flavones Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Bcl-2 Family COX Apoptosis

Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression . Jaceosidin exhibits anti-cancer , anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation .
1
API-1
API-1
0 Images
1 Cited Publications
製品番号: HY-110077
CAS 番号: 36707-00-3
純度:  99.62%
Target:  

Akt Apoptosis Caspase PARP

研究分野:  

Cancer

API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt (IC50 = 0.8 μM). API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model .
PH11
PH11
0 Images
製品番号: HY-116497
CAS 番号: 1627843-95-1
Target:  

FAK

研究分野:  

Cancer

PH11 is a novel focal adhesion kinase (FAK) inhibitor that rapidly induces apoptosis in TRAIL-resistant PANC-1 cells when combined with TRAIL, but has no effect on normal human fibroblasts. The study found that PH11 downregulates c-FLIP through inhibition of FAK and phosphatidylinositol-3-kinase (PI3K)/AKT pathways, thereby restoring the TRAIL apoptotic pathway, suggesting that this combination therapy may provide an attractive therapeutic strategy for the safe and effective treatment of pancreatic cancer. PH11 selectively inhibits c-FLIP expression by modulating upstream signaling pathways and may represent an innovative therapeutic strategy. Although further work is needed to fully elucidate the mechanism of PH11-induced TRAIL sensitization, we believe that our results will provide a new approach to target c-FLIP without the risk of interfering with caspase-8 processing, which could potentially lead to TRAIL resistance. This study also suggests a role for the FAK/AKT signaling pathway in regulating c-FLIP expression in TRAIL-induced apoptosis, and this understanding will provide important clues to control the resistance mechanism to optimize the potential of TRAIL-based pancreatic cancer treatment.
Amentoflavone (Standard)
Amentoflavone (Standard)
0 Images
製品番号: HY-N0662R
CAS 番号: 1617-53-4
別名: Didemethyl-ginkgetin (Standard)
Category:  

Flavonoids Phenols Polyphenols Selaginellaceae Plants Selaginella tamariscina (P. Beauv.) Spring Biflavones

Target:  

Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor

Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .
Guggulsterone (Standard)
Guggulsterone (Standard)
0 Images
製品番号: HY-107738R
CAS 番号: 95975-55-6
別名: Z/E-Guggulsterone (Standard)
Category:  

Triterpenes Terpenoids Plants Burseraceae Commiphora wightii

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards

Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.
Apoptosis inducer 7
Apoptosis inducer 7
0 Images
製品番号: HY-149017
CAS 番号: 2252278-57-0
Target:  

Apoptosis

研究分野:  

Cancer

Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .
Jaceosidin (Standard)
Jaceosidin (Standard)
0 Images
製品番号: HY-N0831R
CAS 番号: 18085-97-7
Category:  

Laburnum anagyroides Medic. Flavonoids Phenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Reference Standards Bcl-2 Family COX Apoptosis

Jaceosidin (Standard) is the analytical standard of Jaceosidin. This product is intended for research and analytical applications. Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression . Jaceosidin exhibits anti-cancer , anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation .
CFLAR Human Pre-designed siRNA Set A
CFLAR Human Pre-designed siRNA Set A
製品番号: HY-RS02570
Target:  

Small Interfering RNA (siRNA)

研究分野:  

Others

CFLAR Human Pre-designed siRNA Set A contains three designed siRNAs for CFLAR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cflar Mouse Pre-designed siRNA Set A
Cflar Mouse Pre-designed siRNA Set A
製品番号: HY-RS21525
Target:  

Small Interfering RNA (siRNA)

研究分野:  

Others

Cflar Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cflar gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

CFLAR Antibody (YA3531)
CFLAR Antibody (YA3531)
0 Images
製品番号: HY-P83834
別名: CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1

Host:  

Mouse

Application:  

WB, IHC-P, FC, ELISA

Reactivity:  

Human, Mouse

CFLAR Antibody (YA3531)(PBS only)
CFLAR Antibody (YA3531)(PBS only)
0 Images
製品番号: HY-P83834A
別名: CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1

Host:  

Mouse

Application:  

WB, IHC-P, FC, ELISA

Reactivity:  

Human, Mouse

OH14
OH14
0 Images
製品番号: HY-182307
CAS 番号: 1018153-87-1
Target:  

Apoptosis Caspase TNF Receptor

研究分野:  

Cancer

OH14 is a cellular FLICE-like inhibitory protein (cFLIP) inhibitor and TNF-related apoptosis-inducing ligand (TRAIL) sensitizer. OH14 selectively binds to the DED1 pocket of cFLIP, disrupting its recruitment to the TRAIL-death inducing signalling complex without affecting procaspase-8 recruitment to FADD, allowing procaspase-8 activation. OH14 promotes TRAIL-mediated apoptosis and impairs cell viability in breast cancer systems when combined with TRAIL. OH14 can be used for the research of breast cancer .
  • 1
Assay Types