1. PI3K/Akt/mTOR
    Apoptosis
  2. Akt
    Apoptosis
  3. API-1

API-1 

Cat. No.: HY-110077
Handling Instructions

API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL).

For research use only. We do not sell to patients.

API-1 Chemical Structure

API-1 Chemical Structure

CAS No. : 36707-00-3

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Description

API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2].

Molecular Weight

337.29

Formula

C13H15N5O6

CAS No.
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API-1
Cat. No.:
HY-110077
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