5 Results for "

human C3aR

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "human C3aR" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-138161
CAS No.: 2411440-41-8
Purity:  99.59%
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

JR14a is a potent thiophene antagonist of human complement C3a receptor. JR14a shows selectivity for the human C3a receptor over C5a receptor. JR14a can suppress C3aR-mediated inflammation .
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2
2 Cited Publications
Cat. No.: HY-P1345A
Target:  

Complement System

Research Areas:  

Neurological Disease Endocrinology

TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca 2+. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .
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Cat. No.: HY-P1345
CAS No.: 869988-94-3
Target:  

Complement System

Research Areas:  

Neurological Disease Endocrinology

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca 2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions .
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Cat. No.: HY-RS01744
Research Areas:  

Others

C3AR1 Human Pre-designed siRNA Set A contains three designed siRNAs for C3AR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P1345C
[DArg10, Aib20] TLQP-21 is a functional antagonist of the complement 3a receptor (C3aR), with EC50 values of 854 nM, 1007 nM, and 1715 nM against human C3aR. [DArg10, Aib20] TLQP-21 recruits β-arrestin, activates Gi3, mediates β-arrestin-dependent receptor internalization, and does not induce calcium influx. [DArg10, Aib20] TLQP-21 inhibits the adrenergic‑induced lipolysis enhancement mediated by TLQP-21 (HY-P1345) and also inhibits the β-hexosaminidase secretion induced by C3a63-77. [DArg10, Aib20] TLQP-21 can be used in research related to asthma and inflammatory diseases .
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