1 Result for "

mouse calvarial bone explants

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "mouse calvarial bone explants" in MCE Product Catalog:

Cat. No.: HY-183378
CAS No.: 132259-06-4
Target:  

MMP

RP 59794 is a potent collagenase (collagenase) and broad-spectrum matrix metalloproteinase (MMP) inhibitor. The active stereoisomer of RP 59794 has a Ki of 13 nM against MMP-1 (with native collagen as substrate) and 45 nM (with a synthetic octapeptide as substrate). RP 59794 blocks and partially dissociates TIMP by binding to the active site of collagenase, specifically inhibits the collagen-transmigrating migration of osteoclasts and bone resorption on collagen-coated surfaces, but exerts no effect on cell migration in collagen-free environments, and acts in a time-dependent manner in bone tissues. RP 59794 can be used in studies of arthritis, periodontal disease, corneal ulcers and tumor invasion .
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