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phospho-CREB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) ERK (1) mAChR (1) Sigma Receptor (1) Tau Protein (1)
By Research Areas:	Neurological Disease (1)

Inhibitors & Agonists

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116586

AF710B	Sigma Receptor mAChR ERK Amyloid-β Tau Protein	Neurological Disease
AF710B is an orally effective allosteric agonist for the M1 muscarinic receptor and σ1 receptor. AF710B activates the downstream phosphorylated ERK1/2 and phosphorylated *CREB* signaling pathways. AF710B simultaneously improves cognitive function and alleviates the core pathological features of Alzheimer's disease, including Aβ deposition, excessive Tau phosphorylation and neuroinflammation. AF710B is applicable to the research of Alzheimer's disease .

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (3) Mouse (2)
Application:	IHC-P (4) ICC/IF (2) IP (4) WB (4) FC (1) ELISA (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Phosphorylated (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80457

	Phospho-CREB (Ser133) Antibody (YA210)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	Phospho-CREB (Ser133) Antibody (YA210) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CREB (Ser133).

HY-P80805

	Phospho-CREB (Ser133) Antibody (YA209) CREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1	WB, IHC-P, IP	Human, Rat
	Phospho-CREB (Ser133) Antibody (YA209) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CREB (Ser133).

HY-P80805A

	Phospho-CREB (Ser133) Antibody (YA209)(PBS only) CREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1	WB, IHC-P, IP	Human, Rat
	Phospho-CREB (Ser133) Antibody (YA209) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CREB (Ser133).

HY-P86100

	Phospho-CREB-1(Ser133) Antibody (YA5792) CREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-CREB-1(Ser133) Antibody (YA5792) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CREB-1(Ser133).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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