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plasminogen modulator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PAI-1 (1) Bacterial (1) Fungal (1) Sodium Channel (1)
By Research Areas:	Cancer (1) Infection (1) Neurological Disease (1)

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Natural
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Targets Recommended: Plasminogen/Plasmin PAI-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100939

4-Chlorophenylguanidine hydrochloride	Sodium Channel	Neurological Disease
4-Chlorophenylguanidine hydrochloride is an *urokinase-type plasminogen* activator inhibitor. 4-Chlorophenylguanidine hydrochloride is a potent ASIC3** positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo .

HY-N16672

SMTP-0 ent-Stachybotrin B	Bacterial Fungal	Infection
SMTP-0 (ent-Stachybotrin B) is an enantiomer of Stachybotrin B isolated from Stachybotrys microspora. SMTP-0 is the simple homologues of the SMTP nonlysine-analog plasminogen modulator family but shows no plasminogen modulator activity. SMTP-0 exhibits antibacterial and antifungal effects. SMTP-0 can be used for the research of infection .

HY-123685

UCD74A (hydrochloride)	PAI-1	Cancer
UCD74A hydrochloride is a 5-substituted Amiloride (HY-B0285) analog and urokinase-type plasminogen activator (uPA) inhibitor with an IC₅₀ of 110 μM. UCD74A hydrochloride modulates plasminogen activation cascades linked to extracellular matrix remodeling. UCD74A hydrochloride can be used for the research of tumor metastasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N16672

SMTP-0 ent-Stachybotrin B	Structural Classification Natural Products Microorganisms Source Classification	Bacterial Fungal
SMTP-0 (ent-Stachybotrin B) is an enantiomer of Stachybotrin B isolated from Stachybotrys microspora. SMTP-0 is the simple homologues of the SMTP nonlysine-analog plasminogen modulator family but shows no plasminogen modulator activity. SMTP-0 exhibits antibacterial and antifungal effects. SMTP-0 can be used for the research of infection .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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plasminogen modulator

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Natural
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