3 Results for "

renal and vascular function

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "renal and vascular function" in MCE Product Catalog:

1
Melamine
Melamine
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1 Cited Publications
Cat. No.: HY-Y1117
CAS No.: 108-78-1
Category:  

Zea mays L. Natural Products Gramineae Other Diseases Plants Disease Research Fields

Target:  

Environmental Pollutants Drug Metabolite Apoptosis COX NADPH Oxidase NF-κB ROS Kinase TGF-β Receptor

Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models .
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Cenupatide
Cenupatide
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Cat. No.: HY-P1615
CAS No.: 1006388-38-0
Synonyms: UPARANT
Target:  

Transmembrane Glycoprotein Formyl Peptide Receptor (FPR) VEGFR Akt STAT JNK p38 MAPK ERK NF-κB Apoptosis Integrin

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cenupatide (UPARANT) is a uPAR and FPR antagonist with anti-angiogenic, anti-inflammatory, and vascular barrier regulatory activities, as well as high stability and resistance to enzymatic degradation in blood/plasma. Cenupatide blocks the uPAR-FPR interaction, reduces VEGF-induced phosphorylation levels of AKT, VEGFR-2, STAT3, JNK, p38 MAPK, ERK1/2, and NF-κB p65, and inhibits αvβ3 integrin activation. Cenupatide suppresses endothelial cell migration, invasion, tube formation, and angiogenic signaling pathways, restores tight junctions and blood-retinal barrier integrity, reduces pro-inflammatory marker levels, and inhibits apoptosis. Cenupatide reduces retinal neovascularization, renal fibrosis, and vascular leakage, and restores visual function in preclinical models. Cenupatide is applicable to research related to retinopathy, diabetic complications, ocular diseases, cancer, and inflammatory diseases .
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14(15)-EpETE
14(15)-EpETE
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Cat. No.: HY-145546
CAS No.: 131339-24-7
Target:  

Cytochrome P450

Research Areas:  

Metabolic Disease

14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function .
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