1 Result for "

reversible knockdown

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "reversible knockdown" in MCE Product Catalog:

Cat. No.: HY-180985
Target:  

PROTACs Bcr-Abl

Research Areas:  

Cancer

Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia .
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