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Results for "

sVEGFR-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) HIF/HIF Prolyl-Hydroxylase (1) IGF-1R (1) Integrin (1) VEGFR (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3226

JB-1	IGF-1R VEGFR Drug Derivative	Cardiovascular Disease Neurological Disease
JB-1, an IGF-I analog, is a selective IGF-I receptor inhibitor that does not interact with IGF-II. JB-1 competes with IGF-I for binding to *IGF-1R* and blocks receptor autophosphorylation. JB-1 increases the level of *sVEGFR-1*. JB-1 normalizes retinal abnormalities, including reducing retinal neovascularization. JB-1 is applicable to studies related to oxygen-induced retinopathy ^[1].

HY-113649

AKB-6899 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects ^[1].

HY-P10097

Flt2-11	VEGFR	Others
Flt2-11 is a anti-angiogenic peptide, and specifically binds NRP-1. Flt2-11 inhibits NRP-1/sVEGFR-1 interaction.

HY-P11649

NYLTHRQ	Integrin VEGFR	Cancer
NYLTHRQ is a peptide. NYLTHRQ specifically blocks the interaction between *sVEGFR1-i13* and β1 integrin, and inhibits the activation of *VEGFR1* and *VEGFR2*. NYLTHRQ inhibits cancer cell proliferation. NYLTHRQ can be used in the research of tumors such as lung squamous cell carcinoma ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P3226

JB-1	IGF-1R VEGFR Drug Derivative	Cardiovascular Disease Neurological Disease
JB-1, an IGF-I analog, is a selective IGF-I receptor inhibitor that does not interact with IGF-II. JB-1 competes with IGF-I for binding to *IGF-1R* and blocks receptor autophosphorylation. JB-1 increases the level of *sVEGFR-1*. JB-1 normalizes retinal abnormalities, including reducing retinal neovascularization. JB-1 is applicable to studies related to oxygen-induced retinopathy ^[1].

HY-P10097

Flt2-11	VEGFR	Others
Flt2-11 is a anti-angiogenic peptide, and specifically binds NRP-1. Flt2-11 inhibits NRP-1/sVEGFR-1 interaction.

HY-P11649

NYLTHRQ	Integrin VEGFR	Cancer
NYLTHRQ is a peptide. NYLTHRQ specifically blocks the interaction between *sVEGFR1-i13* and β1 integrin, and inhibits the activation of *VEGFR1* and *VEGFR2*. NYLTHRQ inhibits cancer cell proliferation. NYLTHRQ can be used in the research of tumors such as lung squamous cell carcinoma ^[1].

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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