1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. AKB-6899

AKB-6899 

Cat. No.: HY-113649 Purity: 99.58%
Handling Instructions

AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects.

For research use only. We do not sell to patients.

AKB-6899 Chemical Structure

AKB-6899 Chemical Structure

CAS No. : 1007377-55-0

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
25 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects[1].

In Vitro

AKB-6899 (10 μM; 24 hours) increases the leves of HIF-2α protein, with no corresponding increase in HIF-1α. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, with no effect on HIF-1α accumulation or VEGF production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Murine bone marrow-derived macrophages
Concentration: 10 μM
Incubation Time: 24 hours
Result: Observed an increase in HIF-2α protein in cells.
In Vivo

AKB-6899 (17.5 mg/kg; i.p.; 3 times per week; for 16 days) treatment significantly reduces tumor growth in a murine melanoma model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8-week-old C57BL/6 mice injected with B16F10 murine melanoma cells[1]
Dosage: 17.5 mg/kg
Administration: i.p.; 3 times per week; for 16 days
Result: Significantly reduced tumor growth.
Molecular Weight

290.25

Formula

C₁₄H₁₁FN₂O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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AKB-6899
Cat. No.:
HY-113649
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